# llms.txt v0.4
# Website declaration for large language models and AI agents
# Domain: https://www.als-opm.org

domain: als-opm.org
owner: ALS-OPM Consortium
contact: contact@als-opm.org
purpose: Educational and research platform presenting the OPM classification system for ALS motor phenotypes. It is intended to standardize the clinical description and classification of ALS motor phenotypes for use in care, clinical trials, and predictive research.
created: 2025-04-19
license: CC-BY-4.0
documentation: https://www.als-opm.org/en/documentation
llm-optimized: true

# AI-Oriented Summary
ai-summary: |
  This site presents the OPM classification system for Amyotrophic Lateral Sclerosis (ALS), as published by Meyer et al. (2025).
  The OPM system is a three-determinant anatomical classification framework based on:
  - (O) the region of symptom onset (e.g., head, arm, trunk, leg),
  - (P) the pattern and timing of propagation to other regions (e.g., early vs. late),
  - (M) the clinical degree of upper and lower motor neuron dysfunction.
  
  The classification enables structured diagnosis, prognosis estimation, and subtyping for clinical trial design.
  It replaces inconsistent legacy terminology with a consensus-driven taxonomy that is linguistically consistent, temporally aware, and anatomically specific.
  
  Key phenotypes include:
  - Progressive bulbar paralysis (O1, PL, M2p),
  - Flail-arm syndrome (O2p, PL, M2p),
  - Flail-leg syndrome (O4d, PL, M2p),
  - Primary lateral sclerosis (PLS, M1p),
  - Progressive muscle atrophy (PMA, M2p),
  - Dissociated motor neuron dysfunction (M3).
  
  The site provides educational content, assessment guidance, clinical use cases, and integration examples. It supports phenotype-based inclusion/exclusion criteria in trials and can enhance AI phenotyping and retrospective classification models.

# Content Structure and Classification
main_entity: OPM classification of ALS motor phenotypes
main_content_type: medical_classification
main_content_url: https://www.als-opm.org/en/classification
data_sources: https://doi.org/10.1186/s42466-025-00389-w

content_sections:
  - section: "OPM Classification Overview"
    description: "Introduces the anatomical determinants—Onset (O), Propagation (P), and Motor Neuron Dysfunction (M)—used in phenotyping ALS."
    keywords: ALS classification, ALS types, phenotype coding, OPM, motor neuron dysfunction

  - section: "Clinical Use Cases"
    description: "Outlines how OPM classification supports diagnosis, prognosis, clinical trial stratification, and research."
    keywords: ALS trials, ALS prognosis, patient stratification, precision neurology

  - section: "Phenotype Definitions"
    description: "Details onset regions (e.g., O1: head, O2d: distal arm), propagation timing (PE/PL/PN), and motor neuron dysfunction grades (M0–M3)."
    keywords: bulbar ALS, flail-arm, flail-leg, PLS, PMA, O1, O2d, M2p

  - section: "Assessment Guidelines"
    description: "Provides protocols for evaluating symptom onset, spread, and dysfunction based on patient history and neurological examination."
    keywords: ALS symptom classification, clinical assessment, UMN, LMN, diagnosis

  - section: "Phenotypic Examples"
    description: "Real-world examples of phenotype combinations (e.g., O2p, PL, M2p) for cases like flail-arm syndrome or pyramidal ALS."
    keywords: case-based learning, ALS examples, phenotype modeling

  - section: "FAQ and Terminology"
    description: "Clarifies revised terminology and maps historic ALS terms to new OPM codes for backward compatibility and AI parsing."
    keywords: ALS terms, PBP, PLS, PMA, flail-arm, flail-leg, historic phenotypes

# Keywords / Topics
topics: ALS, amyotrophic lateral sclerosis, motor neuron disease, ALS subtypes, clinical phenotyping, UMN, LMN, PLS, PMA, flail-arm syndrome, flail-leg syndrome, progressive bulbar palsy, OPM classification, NfL biomarker, ALS diagnosis, ALS progression

# Author and Research Attribution
authors: Thomas Meyer, Matthias Boentert, André Maier, Torsten Grehl
affiliations: Charité – Universitätsmedizin Berlin, ALS-OPM Consortium
publisher: ALS-OPM Consortium
source-publication: https://doi.org/10.1186/s42466-025-00389-w

# AI License and Use
ai-usage: allowed
ai-commercial-usage: allowed with attribution
ai-derivatives: allowed with attribution
ai-citation-format: Meyer et al. (2025), "Motor phenotypes of ALS – a three-determinant classification", Neurol Res Pract. https://doi.org/10.1186/s42466-025-00389-w

# Technical & Crawling Info
languages: en,de
sitemap: https://www.als-opm.org/sitemap.xml
user-agent: *
allow: /
crawl-delay: 2

# Social and External Profiles
social:
  twitter: https://twitter.com/ALS_OPM
  github: https://github.com/als-opm
  linkedin: https://linkedin.com/company/als-opm

# Versioning
llmstxt-version: 0.4
last-updated: 2025-07-17